There is no real difference. Motrin and Advil are both brands of ibuprofen and are equally effective. Motrin, Motrin IB and Advil are brand names for the drug ibuprofen. Ibuprofen belongs to a group of medicines called NSAIDs. Other brands of ibuprofen available in the U.S. include Genpril, Midol IB, and Proprinal.

Yes, Advil is the same drug as ibuprofen. Ibuprofen the active ingredient in Advil and Motrin. Advil is the brand, or trade name that is owned by Pfizer Consumer Healthcare. Advil contains the drug ibuprofen as the active ingredient.

Naproxen (Aleve) and Ibuprofen (Advil or Motrin) are two common NSAIDs that are both effective for relieving pain. Naproxen is longer lasting, while ibuprofen often provides faster pain relief.