Introduction COVID-19 patients with abnormal liver tests, especially ALT and AST, are at higher risk of progressing to severe disease. There is a discrepancy between gamma glutamyl transferase (GGT) ...

Afferent fibres convey sensory information from the upper gastrointestinal tract to the central nervous system but the nature of this information is different for vagal and spinal pathways. Vagal ...

Correspondence to Professor Filip Krag Knop, Center for Clinical Metabolic Research, Copenhagen University Hopital - Herlev and Gentofte, Hellerup, DK-2900, Denmark; filip.krag.knop.01{at}regionh.dk; ...

Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular ...

1 Cancer Research UK Colorectal Cancer Unit, St Mark’s Hospital, Harrow, Middlesex HA1 3UJ, UK 2 Wolfson Unit for Endoscopy, St Mark’s Hospital Most colon cancers are assumed to have a premalignant ...

Objective An international meeting was organised to develop consensus on (1) the landmarks to define the gastro-oesophageal junction (GOJ), (2) the occurrence and pathophysiological significance of ...

Objective Dietary fibres are essential for maintaining microbial diversity and the gut microbiota can modulate host physiology by metabolising the fibres. Here, we investigated whether the soluble ...

1 Division of Molecular and Genetic Medicine, Royal Hallamshire Hospital, Sheffield, UK 2 Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, UK 3 Gastroenterology Unit, John ...

Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common chronic liver disease globally and is currently estimated to affect up to 38% of the global adult population. NAFLD is a ...

Correspondence to Dr Jonathan Hoare, Department of Gastroenterology, Imperial College Healthcare NHS Trust, London, UK; j.hoare{at}ic.ac.uk This is the first UK national guideline to concentrate on ...

Background and aims Chronic inflammation induced by chronic hepatitis B virus (HBV) infection increases the risk of hepatocellular carcinoma (HCC). However, little is known about the immune landscape ...

Functional dyspepsia is a symptom complex characterised by postprandial upper abdominal discomfort or pain, early satiety, nausea, vomiting, abdominal distension, bloating, and anorexia in the absence ...