The risk of second tumors after chimeric antigen receptor (CAR) T-cell therapy, especially the risk of T-cell neoplasms related to viral vector integration, is an emerging concern. A total of 724 ...

Indolent CD4+ cytotoxic chimeric antigen receptor (CAR) T-cell lymphoma involving the small intestine was diagnosed in a patient who had previously received ciltacabtagene autoleucel (cilta-cel ...

A 32-year-old man presented with a 7-year history of skin nodules and swelling, pain, and morning stiffness in his fingers ...

A total of 742 patients underwent randomization, with 371 assigned to each group. The analysis of the primary outcome included 722 patients. The median hemoglobin level in the intensive care unit ...

Acute kidney injury (AKI) is a serious and common complication of cardiac surgery, for which reduced kidney perfusion is a key contributing factor. Intravenous amino acids increase kidney ...

The last three decades have seen dramatic advances in the use of immunotherapies to treat cancer, primarily in the form of monoclonal antibodies targeting cancer cells directly or recruiting the ...

Among critically ill adults undergoing tracheal intubation, hypoxemia increases the risk of cardiac arrest and death. The effect of preoxygenation with noninvasive ventilation, as compared with ...

Genetic variants that cause rare disorders may remain elusive even after expansive testing, such as exome sequencing. The diagnostic yield of genome sequencing, particularly after a negative ...

Among 15 patients with relapsed ALCL after the failure of brentuximab vedotin therapy, the ALK inhibitor brigatinib led to a complete response in 73%, and progression-free survival at 2 years was 73%.

Dr. Kevin S. Oh (Radiation Oncology): A 45-year-old woman was evaluated in the oncology clinic of this hospital because of metastatic triple-negative breast cancer. The patient had been well until ...

Magnesium is an important cofactor for numerous enzymes. All ATPase reactions require Mg 2+ –ATP, including those involved in RNA and DNA biologic functions. It opposes calcium actions and acts ...

In a phase 3 trial, bulevirtide monotherapy led to a virologic response in patients with chronic hepatitis D. Pegylated interferon (peginterferon) alfa-2a is recommended by guidelines as an off ...