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Major Finding: AARS1 mediates protein lactylation that couples cell metabolism and p53 tumor suppressor function. Concept: AARS1 lactylates p53 at lysines 120 and 139 to block DNA binding and ...
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1Fox Chase, Philadelphia, PA.
Antibody drug conjugates (ADCs) consist of an antibody, a cytotoxic payload, and a linker between the two. ADCs are becoming increasingly used in metastatic bladder cancer. Enfortumab vedotin (EV) in ...
1Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan. 2Department of Chemistry, Chung Yuan Christian University, Taoyuan, Taiwan.
The FDA greenlighted tarlatamab (Imdelltra; Amgen), a bispecific T-cell engager that targets delta-like ligand 3 (DLL3), to treat extensive-stage small cell lung cancer that has advanced despite ...
1XRad Therapeutics, Orlando, Florida.
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1Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...
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